So, we have an Anti-Antimeme: an idea that starts in millions of people and starts shrinking, eight people forgetting the info at a time.
No idea what the info is. May even blackbox it. Something to do with eight.
But I do know that as the information shrinks, the people who know start getting more and more aware that they are the only ones. They start becoming confused and paranoid, eventually forming a sort of cult. As the members of the cult forget, the members who forgot (known by the Church of the Eight Disciples as the Forgotten) are brutally murdered and their blood used to write the info (which suddenly becomes the "Eight Sacred Scriptures") down on scrolls and tapestries. It eventually comes down to one man, Guru Vito, who cannibalizes the eight remaining Forgotten, stabs himself eight times, and lives eight hours before instantly expiring, painting upon the walls with his own blood the same info eight hundred times. Later tests revealed that the info had minor cognitohazardous effects: people who knew it were just slightly more drawn to others who knew it, and slightly more adverse to people who didn't. At the start, which using Foundation computers they guess happened in August 8th, 1888, exactly 16,777,216 people knew of the anti-antimeme, AKA 8^8. The less people who knew, the more potent the effects were, especially if the number was a multiple of eight or contained the number eight. Writing it down also made it more potent, especially if the number of iterations was a multiple of eight, contained the number eight,or was written on things with dimensions that were multiples of eight or contained the number eight. Gatherings of people who knew also amplified the effects, espec-you get the idea?
The building was designated a quarantine shortly after, but it's implied that some crazy stoned people from one of the minor GOIs (maybe Fifthists) snuck in mere days before the quarantine and are currently in hiding, trying to spread the anti-antimeme.
